Figure 1. Aurora A kinase inhibitors attenuate 2-ME induced AR degradation.
(A-B) LNCaP and C4-2, (C) 22RV1 and (D) LAPC4 cells were treated with or without 2-ME in presence or absence of Aurora A kinase inhibitor MLN8054 and/or VX-680 for 24 h. Cells were harvested, lysed and extracts were immunoblotted for indicated proteins. Tubulin served as loading control.