TABLE 2.
HLMs | [Substrate] (µM) | Testosterone Metabolite Formation (pmol/min/mg protein) |
2α-OH-T/6β-OH-T Ratio | ||
---|---|---|---|---|---|
6β-OH-T | 2β-OH-T | 2α-OH-T | |||
Adult | |||||
Lot DDV | 50 | 1167.5 | 67.5 | 2.5 | 0.002 |
100 | 3377.6 | 284.9 | 8.6 | 0.003 | |
250 | 1805.7 | 134.3 | 3.7 | 0.002 | |
Lot RGS | 50 | 55.4 | 3.1 | ND | NA |
100 | 182.7 | 14.3 | BLQ | NA | |
250 | 101.7 | 6.5 | ND | NA | |
Fetal | |||||
Lot 5 | 50 | 6.7 | BLQ | 7.0 | 1.054 |
100 | 14.9 | BLQ | 19.9 | 1.336 | |
250 | 12.9 | BLQ | 4.5 | 0.351 | |
Lot 18 | 50 | 5.4 | BLQ | 5.4 | 0.993 |
100 | 11.6 | BLQ | 10.5 | 0.905 | |
250 | 8.5 | BLQ | 2.1 | 0.246 |
NA, not applicable; ND, not detected.