Table 3.
Correlation Between Clinicopathological Features, TGM2, TXNIP Expression, Ki Labeling Index, Disease Recurrence, Survival and Response to Therapy in Our Patients
| Outcome | All | TGM2 | p-value‡ | TXNIP | p-value‡ | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Low | High | Low | High | |||||||||
| (N=50) | (N=29) | (N=21) | (N=22) | (N=28) | ||||||||
| No. | (%) | No. | (%) | No. | (%) | No. | (%) | No. | (%) | |||
| Surgery | ||||||||||||
| Gross tumor resection | 27 | (54%) | 25 | (86.20%) | 2 | (9.50%) | <0.001 | 3 | (13.60%) | 24 | (85.70%) | <0.001 |
| Near total resection | 11 | (22%) | 2 | (6.90%) | 9 | (42.90%) | 8 | (36.40%) | 3 | (10.70%) | ||
| Subtotal resection | 7 | (14%) | 2 | (6.90%) | 5 | (23.80%) | 6 | (27.30%) | 1 | (3.60%) | ||
| Biopsy | 5 | (10%) | 0 | 0%) | 5 | (23.80%) | 5 | (22.70%) | 0 | 0%) | ||
| Simpson grading system | ||||||||||||
| Grade I | 11 | (22%) | 11 | (37.90%) | 0 | 0%) | <0.001 | 0 | 0%) | 11 | (39.30%) | <0.001 |
| Grade II | 16 | (32%) | 14 | (48.30%) | 2 | (9.50%) | 3 | (13.60%) | 13 | (46.40%) | ||
| Grade III | 11 | (22%) | 2 | (6.90%) | 9 | (42.90%) | 8 | (36.40%) | 3 | (10.70%) | ||
| Grade IV | 7 | (14%) | 2 | (6.90%) | 5 | (23.80%) | 6 | (27.30%) | 1 | (3.60%) | ||
| Grade V | 5 | (10%) | 0 | 0%) | 5 | (23.80%) | 5 | (22.70%) | 0 | 0%) | ||
| Residual | ||||||||||||
| Absent | 27 | (54%) | 25 | (86.20%) | 2 | (9.50%) | <0.001 | 3 | (13.60%) | 24 | (85.70%) | <0.001 |
| Present | 23 | (46%) | 4 | (13.80%) | 19 | (90.50%) | 19 | (86.40%) | 4 | (14.30%) | ||
| Radiotherapy | ||||||||||||
| No | 26 | (52%) | 24 | (82.80%) | 2 | (9.50%) | <0.001 | 2 | (9.10%) | 24 | (85.70%) | <0.001 |
| Yes | 24 | (48%) | 5 | (17.20%) | 19 | (90.50%) | 20 | (90.90%) | 4 | (14.30%) | ||
| Response | (N=23) | (N=4) | (N=19) | (N=19) | (N=4) | |||||||
| OAR | 19 | (82.60%) | 2 | (50%) | 17 | (89.50%) | 0.125 | 15 | (78.90%) | 4 | (100%) | 1 |
| NR | 4 | (17.40%) | 2 | (50%) | 2 | (10.50%) | 4 | (21.10%) | 0 | 0%) | ||
| CR | 17 | (73.90%) | 2 | (50%) | 15 | (78.90%) | 0.289 | 13 | (68.40%) | 4 | (100%) | 0.635 |
| PR | 2 | (8.70%) | 0 | 0%) | 2 | (10.50%) | 2 | (10.50%) | 0 | 0%) | ||
| SD | 2 | (8.70%) | 1 | (25%) | 1 | (5.30%) | 2 | (10.50%) | 0 | 0%) | ||
| PD | 2 | (8.70%) | 1 | (25%) | 1 | (5.30%) | 2 | (10.50%) | 0 | 0%) | ||
| Recurrence | (N=45) | (N=28) | (N=17) | (N=17) | (N=28) | |||||||
| Absent | 32 | (71.10%) | 28 | (100%) | 4 | (23.50%) | <0.001 | 5 | (29.40%) | 27 | (96.40%) | <0.001 |
| Present | 13 | (28.90%) | 0 | 0%) | 13 | (76.50%) | 12 | (70.60%) | 1 | (3.60%) | ||
| Survival | (N=50) | (N=29) | (N=21) | (N=22) | (N=28) | |||||||
| Absent | 33 | (66%) | 29 | (100%) | 4 | (19%) | <0.001 | 6 | (27.30%) | 27 | (96.40%) | <0.001 |
| Present | 17 | (34%) | 0 | 0%) | 17 | (81%) | 16 | (72.70%) | 1 | (3.60%) | ||
Categorical variables were expressed as number (percentage), continuous variables were expressed as mean ± SD & median (range)
‡
Chi-square test; p< 0.05 is significant.