Table 1.
Liver chemistries for subject meeting Hy's Law criteria in phase Ia trial
| Study day | Actual values | Multiples of ULNa | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
|
AST (U/L) |
ALT (U/L) |
DBIL (mg/dL) |
TBIL (mg/dL) |
ALP (U/L) |
INR |
AST (41) |
ALT (63) |
DBIL (0.3) |
TBIL (1.2) |
ALP (126) |
|
| −16b | 42 | 40 | 0.3 | 1.1 | 50 | 1 | 1.0 | 0.6 | 1.0 | 0.9 | 0.4 |
| −1c | 42 | 30 | 0.4 | 1.2 | 53 | 1 | 1.0 | 0.5 | 1.3 | 1.0 | 0.4 |
| 0 | 57 | 33 | 0.5 | 1.0 | 50 | ND | 1.4 | 0.5 | 1.7 | 0.8 | 0.4 |
| 1 | 32 | 27 | 0.4 | 1.1 | 49 | 1 | 0.8 | 0.4 | 1.3 | 0.9 | 0.4 |
| 2 | 227 | 220 | ND | 4.6 | 94 | ND | 5.5 | 3.5 | ND | 3.8 | 0.7 |
| 3 | 243 | 233 | ND | 4.8 | 103 | ND | 5.9 | 3.7 | ND | 4.0 | 0.8 |
| 4 | 184 | 216 | 3.8 | 6.3 | 143 | ND | 4.5 | 3.4 | 12.7 | 5.2 | 1.1 |
| 8 | 62 | 130 | 0.8 | 2.0 | 146 | 1.1 | 1.5 | 2.1 | 2.7 | 1.7 | 1.2 |
| 15 | 45 | 77 | 0.4 | 1.3 | 108 | ND | 1.1 | 1.2 | 1.3 | 1.1 | 0.9 |
| 21 | 49 | 60 | 0.3 | 1.3 | 73 | 1.2 | 1.2 | 1.0 | 1.0 | 1.1 | 0.6 |
| 117 | 32 | 30 | 0.2 | 0.8 | 50 | ND | 0.8 | 0.5 | 0.7 | 0.7 | 0.4 |
AST, aspartate transaminase; ALT, alanine transaminase; DBIL, direct bilirubin; TBIL, total bilirubin; ALP, alkaline phosphatase; INR, international normalized ratio; ULN, upper limit of normal; ND, not determined.
a
Numbers in parentheses are the upper limits of normal (ULN).
b
Screening.
c
Baseline.