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. 2017 Nov 19;15(4):1559325817739760. doi: 10.1177/1559325817739760

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© The Author(s) 2017

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 2. — Bidirectional regulation of mouse embryonic stem cell (mESC) proliferation by nicotine exposure at indicated concentrations for 48 hours. Cell proliferation was analyzed by BrdU incorporation assay (A) and cell proliferation assay kit (CCK-8 assay; B). Data were represented as mean (standard deviation). *P < .05, **P < .01 compared to control (0 μM group, first column).