Table 2.
IC50 values of 25, 35, 37, 45, 48 and 54 on different PI3K isoforms.[a]
|
|||||||
|---|---|---|---|---|---|---|---|
| IC50 [μm] | |||||||
| TGX155 | 25 | 35 | 37 | 45 | 48 | 54 | |
| PI3Kα | >10 | 0.74±0.31 | 1.3±0.7 | 0.018±0.004 | 0.32±0.2 | 2.65±0.8 | 0.26±0.12 |
| PI3Kβ | 0.096±0.007 | 5.5±2.5 | 9.3±5.8 | 0.059±0.015 | 0.30±0.2 | 0.10±0.04 | 1.1±0.5 |
| PI3Kγ | 9.40±1.2 | 3.0±1.0 | 4.2±2.1 | 0.186±0.043 | 0.30±0.2 | 1.0±0.5 | 1.4±0.44 |
| PI3Kδ | 0.41±0.13 | 0.61±0.27 | 0.81±0.36 | 0.019±0.004 | 0.17±0.1 | 0.47±0.26 | 0.35±0.17 |
| PI3Kc2α | n.d. | n.d. | n.d. | 3.7±1.1 | n.d. | n.d. | n.d. |
| PI3Kc2β | n.d. | n.d. | n.d. | >20 | n.d. | n.d. | n.d. |
| PI3Kc2γ | n.d. | n.d. | n.d. | 2.8±0.7 | n.d. | n.d. | n.d. |
| PI3Kc3 | n.d. | n.d. | n.d. | 0.59±0.2 | n.d. | n.d. | n.d. |
[a] Values are the means of at least three determinations in multiple experiments, with 95 % confidence intervals; n.d.: not determined.