Table 2.
Metabolite | Normal liver: Scan 1 / mmol/L wet tissue | Normal liver : Scan 2 / mmol/L wet tissue | Cirrhotic liver / mmol/L wet tissue | Difference between normal (scan 1) and cirrhotic livers/ % | P‐Value |
---|---|---|---|---|---|
α‐ATP | 2.74 ± 0.11 | 2.69 ± 0.18 | 2.81 ± 0.11 | 2.3 | 0.10 |
Pi | 2.23 ± 0.20 | 2.18 ± 0.18 | 1.96 ± 0.23 | −12.2 | 0.005** |
GPC | 2.34 ± 0.46 | 2.35 ± 0.48 | 2.55 ± 0.59 | 9.1 | 0.18 |
GPE | 1.50 ± 0.28 | 1.49 ± 0.21 | 1.82 ± 0.47 | 20.9 | 0.04* |
PC | 1.06 ± 0.16 | 0.99 ± 0.17 | 0.93 ± 0.24 | −12.2 | 0.08 |
PE | 0.77 ± 0.14 | 0.70 ± 0.11 | 0.76 ± 0.11 | −1.47 | 0.42 |
PtdC/PEP | 1.38 ± 0.31 | 1.35 ± 0.38 | 1.06 ± 0.32 | −23.2 | 0.016* |
NAD+ | 2.37 ± 0.14 | 2.33 ± 0.27 | 2.41 ± 0.38 | 1.7 | 0.38 |
UDPG | 2.00 ± 0.22 | 2.06 ± 0.17 | 1.99 ± 0.37 | −0.6 | 0.47 |
PDE | 3.84 ± 0.68 | 3.84 ± 0.66 | 4.37 ± 0.92 | 13.7 | 0.08 |
PME | 1.83 ± 0.27 | 1.69 ± 0.24 | 1.69 ± 0.28 | −7.7 | 0.12 |
The concentrations are based on a 2.65 mmol/L wet tissue γ‐ATP concentration. This assumption is reasonable for the normal volunteers, but does not necessarily hold for cirrhosis. The PDE concentration is the sum of the GPC and GPE concentrations, and the PME concentration is the sum of the PC and PE concentrations. Significant differences between healthy and cirrhotic concentrations are marked with stars: * P < 0.05, ** P < 0.01.