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The one‐carbon cycle. The actions of folate hydrolase 1 (FOLH1), methylene tetrahydrofolate reductase (MTHFR) and catechol‐O‐methyltransferase (COMT) are highlighted in blue. Note that the activity of all S‐adenosylmethionine (SAM)‐dependent methyltransferases results in SAM's conversion to S‐adenosylhomocysteine (indicated by the conversion of “R” to “R‐CH 3”). THF, tetrahydrofolate; MTHF, 5,10‐methylene tetrahydrofolate
