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. 2017 Aug 20;19(6):477–486. doi: 10.1111/bdi.12531

Figure 4.

Figure 4

Folic acid (FA) administration robustly altered one‐carbon metabolism. Serum folate increased (A), and total homocysteine decreased (B), from baseline to 12 weeks in those randomized to FA (shown in red; n=43 for folate; n=39 for total homocysteine), but not placebo (shown in blue; n=32 for folate; n=29 for total homocysteine). Darker colours indicate those randomized to lamotrigine (Lam) and lighter colours those randomized to placebo (Pbo)