Figure 4.
Folic acid (FA) administration robustly altered one‐carbon metabolism. Serum folate increased (A), and total homocysteine decreased (B), from baseline to 12 weeks in those randomized to FA (shown in red; n=43 for folate; n=39 for total homocysteine), but not placebo (shown in blue; n=32 for folate; n=29 for total homocysteine). Darker colours indicate those randomized to lamotrigine (Lam) and lighter colours those randomized to placebo (Pbo)