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. Author manuscript; available in PMC: 2017 Nov 21.
Published in final edited form as: ACS Chem Biol. 2017 Jul 26;12(9):2287–2295. doi: 10.1021/acschembio.7b00388

Table 2.

Ecteinamycin Sensitive E. coli Deletion Mutants

disrupted gene fold change adj. P value gene function
 acrB 0.086930074 1.49e−65 component of AcrAB-ToIC multidrug efflux system
 acrA 0.08687022 2.59e−60 component of AcrAB-ToIC multidrug efflux system
 trkA 0.145154921 4.19e−27 NAD-binding component of TrK potassium transporter
 sapD 0.196735935 4.74e−21 component of peptide uptake ABC trans-porter, required for ATP-dependence of TrK K+ uptake systems
 csgE 0.368679357 9.8e−20 component of curli secretion and assembly complex
 ldcA 0.341380178 3.45e−18 L,D-carboxypeptidase A; cytoplasmic protease that cleaves the terminal D-alanine from cytoplasmic muropeptides
 sapB 0.241016831 1.28e−16 component of peptide uptake ABC transporter
 kdpD 0.373882707 2.10e−15 sensor kinase for the kdp (K+-dependence) operon
 fis 0.416051589 9.27e−15 transcriptional activator for rRNA operons, bends DNA
 rpoS 0.35004657 1.15e−13 component of RNA polymerase σ 38