Table 2.

Characteristics of SNPs Selected for Genotyping

SNPs	Locus	Gene	minor allele	MAF	Previously observed effects of SNPs on CPD (8)(6) or CPD levels (1-10 CPD, 11-20, 21- 30 and >=31) (7)
					ß	P	Ref
rs215614a	7p14	PDE1C	G	0.36	0.22	2*10−7	(8)
rs13273442b	8p11	CHNB3	A	0.23	−0.29	4*10−8	(8)
rs1329650	10q23	LOC100188947	T	0.29	−0.37	6*10−10	(6)
rs1028936	10q23	LOC100188947	C	0.19	−0.45	1*10−9	(6)
rs16969968	15q25	CHRNA5	A	0.39	1.00 0.08	6*10−72 4*10−65	(6) (7)
rs578776	15q25	CHRNA3	A	0.27	−0.06	7*10−37	(7)
rs4105144	19q13	2Kb 5′ CYP2A6	T	0.35	−0.39	2*10−12	(8)
rs3733829	19q13	EGLN	G	0.36	0.33	1*10−8	(6)
rs7937	19q13	UTR RAB4B	C	0.46	−0.24	2*10−9	(8)
rs7260329	19q13	Intron, CYP2B6	T	0.32	−0.20	5*10−6	(8)

Abbreviations: CPD, number of cigarettes per day; MAF, Minor Allele Frequency; SNP, single-nucleotide polymorphism

^aGenotyped instead of proxy rs215605 (r²=1.0; d′=1.0 )

^bGenotyped instead of proxy SNPs rs6474412 (r²=1.0; d′=1, effect on CPD ß= 0.30, s.e.=0.05, P= 1.7 × 10^{−8 ((8))}) and rs13280604 (r²=1.0; d′=1.0, effect on CPD ß= 0.31, s.e.=0.05, P= 1.3 × 10^{−8 ((8))}).