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. Author manuscript; available in PMC: 2017 Nov 21.
Published in final edited form as: Mol Pharm. 2017 Oct 25;14(11):3709–3717. doi: 10.1021/acs.molpharmaceut.7b00469

Table 4.

Pharmacodynamic parameters of iNos expression estimated from the designated PK-PD model shown in Figure 2.

PD parameter Estimation CV(%)
Slps 185.8 24.03
τ (h) 0.680 Fixed
Km (h-1) 0.614 20.45
Kin_iNos (h-1) 1.474 38.59
Imax 1.0 Fixed
IC50 (μg/mL) 0.423 67.33