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. 2017 Nov 21;12(11):e0188417. doi: 10.1371/journal.pone.0188417

Fig 7. Loss of Rictor from GABAergic interneurons does not alter interneuron number or contribute to hypomyelination.

Fig 7

To determine if loss of Rictor from GABAergic interneurons may alter interneuron proliferation, the number of parvalbumin and GAD67 expressing interneurons was determined in control (A-C, G-H) and CKO (D-H) cortex (Inset A, while box denotes location of images). Data represents mean +/- SEM compared with Student’s t-test, n = 6–7 per group, *p<0.05. Scale bar = 200 μm. To determine if loss of Rictor from GABAergic interneurons may contribute to hypomyelination, Rictor was inactivated in interneuron progenitors using Nkx2.1-Cre. Expression of the myelin associated proteins MBP, CNPase and MAG was determined in P30-P60 cortex. Data represent mean +/- SEM compared with Student’s t-test, n = 4 animals per group.*p<0.05.