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. 2017 Nov 21;12(11):e0188520. doi: 10.1371/journal.pone.0188520

Fig 1. Alignment of F. hepatica MF6p/FhHDM-1 protein with whole mature sequences and truncated fragments of protein orthologs from other trematodes with sequence homology.

Fig 1

Aligned sequences from F. hepatica (MF6p/FhHDM-1), F. gigantica (MF6p/FgHDM-1), D. dendriticum (MF6p/DdHDM-1), F. hepatica truncated peptides (sFhMF6a, sFhMF6c, sFhMF6c1-4), and truncated peptides corresponding to the C-terminal region from C. sinensis (sCsMF6c), O. viverrini (sOvMF6c) and P. westermani (sPwMF6c) are shown. Synthetic or native (from whole parasite extracts) peptide/proteins used in the study are indicated by adding, respectively, an “s” or an “n” before the corresponding name. The sequences of MF6p/FhHDM-1 recognized by mAb MF6 are highlighted in bold. Amino acid residues in common with the MF6 epitope (residues 56–81) are shown in green. The unique amino acid difference between the F. hepatica and F. gigantica protein is indicated in red color. The truncated fragment corresponding to the heme-binding region of MF6p/FhHDM-1 is underlined.