Table 1.

Single-Marker Family-Based Association Analysis of IFIH1 Markers

dbSNP ID (137)	Exon/Intron	cDNA Change	Amino Acid Change	MAF	Familya (n)	Zb	P Valueb
rs35744605	Exon 10	c.1879G>T	p.Glu627Ter	0.0034	36	-0.792	0.43
rs72650663	Exon 11	c.2105C>T	p.Thr702Ile	0.0029	26	-0.854	0.39
rs3747517	Exon 13	c.2528A>Gc	p.His843Arg	0.27(A)	1592	-3.925(A)	0.000087
rs35667974	Exon 14	c.2767A>G	p.Ile923Val	0.0087	84	-2.902	0.0037
rs35732034	Intron 14	c.2807+1G>A	--	0.0061	66	-1.300	0.19
rs1990760	Exon 15	c.2836G>Ad	p.Ala946Thr	0.41(G)	1755	-4.369(G)	0.000012

Abbreviations are as follows: MAF, minor allele frequency; n, number.

Variant locations are based on reference gene accessions NM_022168.2 and NP_071451.2.

^aT1D sibpair/trio families collected by the Type 1 Diabetes Genetics Consortium.

^bZ scores and p values were calculated for the minor alleles.

^cA is the minor allele, which is opposite to dbSNP

^dG is the minor allele, which is opposite to dbSNP