Table 2.

Family-Based Haplotype Association Analysis of IFIH1

Haplotype	rs35744605	rs72650663	rs3747517	rs35667974	rs35732034	rs1990760	Freq.	Familya (n)	Z	P Value
H1	2 G	2 C	2 G Arg	2 A	2 G	2 A Thr	0.571	1678	4.797	1.61×10-6
H2	2 G	2 C	1 A His	2 A	2 G	1 G Ala	0.269	1500	-3.309	9.35×10-4
H3	2 G	2 C	2 G Arg	2 A	2 G	1 G Ala	0.141	1009	-1.119	0.26
H4	2 G	2 C	1 A His	1 G	2 G	1 G Ala	0.009	86	-3.022	0.0025
H5	1 T	2 C	2 G Arg	2 A	2 G	2 A Thr	0.003	36	-0.815	0.42
H6	2 G	2 C	2 G Arg	2 A	1 A	2 A Thr	0.003	40	-0.980	0.33
H7	2 G	1 T	2 G Arg	2 A	1 A	2 A Thr	0.003	26	-0.854	0.39
H8	2 G	2 C	1 A His	2 A	2 G	2 A Thr	<0.001	2	-0.999	0.32

Abbreviations are as follows: 1, minor allele; 2, major allele; freq., frequency, n, number.

^aT1D sibpair/trio families collected by the Type 1 Diabetes Genetics Consortium.