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. 2017 Sep 12;66(12):3111–3121. doi: 10.2337/db16-1182

Figure 2.

Figure 2

miR-146a treatment improves neurological function. A: Schematic diagram shows the treatment regimen of male db/db mice. Green arrows indicate time points of electrophysiological tests, and red arrows indicate time points of behavioral tests. Improved neurological function measured by MCV (B), SCV (C), radial heat plate test (D), and tail flick test (E) in db/db mice treated with miR-146a mimics (db/db + miR-146a, 5 and 10 mg/kg; n = 13/group) are shown. *P < 0.05 vs. nondiabetic mice (db/m; n = 10); #P < 0.05 vs. diabetic mice treated with control (con) miRNA mimics (db/db + miR con; n = 13). w, weeks.