Table 1.
Physical and metabolic characteristics in obese youth with IGT vs. NGT
| NGT (n = 97) | IGT (n = 41) | P | |
|---|---|---|---|
| Physical characteristics | |||
| Age (years) | 14.3 ± 0.2 | 14.7 ± 0.4 | NS |
| Sex (male/female), n (%) | 35 (36)/62 (64) | 9 (22)/32 (78) | NS |
| Race (AA/AW), n (%) | 46 (47)/51 (53) | 13 (32)/28 (68) | NS |
| Tanner stage (III/IV/V), n (%) | 26 (27)/18 (18)/53 (55) | 4 (10)/7 (17)/30 (73) | NS |
| BMI (kg/m2) | 34.4 ± 0.6 | 36.9 ± 1.0 | 0.029 |
| BMI z score | 2.20 ± 0.05 | 2.35 ± 0.05 | 0.018 |
| Total fat mass (kg) | 38.5 ± 1.3 | 43.2 ± 1.7 | 0.046 |
| Fat-free mass (kg) | 48.0 ± 1.0 | 51.0 ± 1.6 | NS |
| Percent body fat (%) | 42.4 ± 0.8 | 44.5 ± 0.8 | NS |
| Total cholesterol (mg/dL) | 161.6 ± 3.2 | 172.9 ± 5.1 | NS |
| Triglyceride (mg/dL) | 116.2 ± 5.5 | 140.4 ± 13.7 | NS |
| HDL (mg/dL) | 41.7 ± 0.9 | 38.2 ± 1.4 | 0.034 |
| LDL (mg/dL) | 96.8 ± 2.9 | 106.9 ± 4.7 | NS |
| VLDL (mg/dL) | 23.2 ± 1.1 | 26.1 ± 2.4 | NS |
| Metabolic characteristics | |||
| HbA1c (%) | 5.26 ± 0.04 | 5.35 ± 0.07 | NS |
| Fasting glucose (mg/dL) | 95.8 ± 0.6 | 97.5 ± 1.2 | NS |
| Fasting insulin (µU/mL) | 35.6 ± 1.6 | 49.6 ± 4.6 | 0.002 |
| Fasting FFAs (mmol/L) | 0.30 ± 0.01 | 0.35 ± 0.02 | 0.070 |
| Steady-state glucose (mg/dL) | 100.6 ± 0.2 | 100.3 ± 0.3 | NS |
| Steady-state insulin (µU/mL) | 283.5 ± 9.5 | 308.0 ± 13.4 | NS |
| Hyperglycemic clamp parameters | |||
| First-phase insulin concentration (µU/mL) | 248.9 ± 19.6 | 219.3 ± 18.8 | NS |
| Second-phase insulin concentration (µU/mL) | 285.5 ± 15.9 | 323.5 ± 28.7 | NS |
Values are reported as mean ± SEM or n (%). AA, African American; AW, American white.