Table 3.
MR estimate of the association between lipids and any DR using SNPs unique to each lipid fraction and independent of glycemic traits# (primary analysis)
| All ethnicities
(N = 2,969 case and 4,096 control subjects) |
Caucasian
(N = 797 case and 1,208 control subjects) |
Chinese
(N = 273 case and 826 control subjects) |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. of SNPs* | OR† (95% CI) | P value | I2, % | No. of SNPs* | OR† (95% CI) | P value | I2, % | No. of SNPs* | OR† (95% CI) | P value | I2, % | |
| HDL |
44 |
0.91 (0.67–1.23) |
0.539 |
0.0 |
44 |
0.99 (0.61–1.60) |
0.960 |
8.3 |
21 |
1.36 (0.29–6.44) |
0.699 |
0.0 |
| LDL |
9 |
2.50 (0.91–6.87) |
0.075 |
0.0 |
9 |
3.93 (0.53–29.33) |
0.182 |
0.0 |
3 |
0.70 (0.01–88.38) |
0.885 |
0.0 |
| Triglycerides |
15 |
1.00 (0.86–1.15) |
0.983 |
0.0 |
15 |
1.05 (0.67–1.65) |
0.828 |
0.0 |
4 |
1.09 (0.05–25.66) |
0.959 |
5.1 |
| Total cholesterol | 18 | 0.83 (0.53–1.31) | 0.424 | 0.0 | 18 | 0.74 (0.42–1.30) | 0.293 | 0.0 | – | – | – | – |
β(SNP-lipid) estimates taken from the GLGC for Caucasians and the AGEN Consortium for Chinese differed. Therefore, we performed analyses in these two populations separately.
*Number of SNPs included in meta-analysis.
†ORs are for a SD of genetically induced increases in plasma lipid profiles.
#Two SNPs that showed genome-wide significant association with glycemic traits were also excluded: rs9686661and rs12328675.