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. 2017 Sep 26;66(12):3130–3141. doi: 10.2337/db17-0398

Table 4.

MR estimate of the association between lipids and any DR for all SNPs (secondary analysis)

All ethnicities
(N = 2,969 case and 4,096 control subjects)
Caucasian
(N = 797 case and 1,208 control subjects)
Chinese
(N = 273 case and 826 control subjects)
No. of SNPs** OR* (95% CI) P value I2, % No. of SNPs** OR* (95% CI) P value I2, % No. of SNPs** OR* (95% CI) P value I2, %
HDL
60
0.94 (0.79–1.14)
0.543
0.0
60
1.02 (0.76–1.35)
0.917
12.8
28
1.16 (0.51–2.63)
0.728
0.0
LDL
30
0.95 (0.75–1.20)
0.651
0.0
30
0.87 (0.60–1.28)
0.487
0.0
10
1.44 (0.31–6.70)
0.641
0.0
Triglycerides
28
1.08 (0.96–1.22)
0.227
0.0
28
1.11 (0.85–1.44)
0.453
0.0
13
1.55 (0.70–3.41)
0.280
0.0
Total cholesterol 39 0.92 (0.74–1.14) 0.438 0.0 39 0.98 (0.70–1.37) 0.889 5.2

β(SNP-lipid) estimates taken from the GLGC for Caucasians and the AGEN Consortium for Chinese differed. Therefore, we performed analyses in these two populations separately.

*ORs are for a SD of genetically induced increases in plasma lipid profiles.

**Number of SNPs included in meta-analysis.