Table 4.
MR estimate of the association between lipids and any DR for all SNPs (secondary analysis)
| All ethnicities
(N = 2,969 case and 4,096 control subjects) |
Caucasian
(N = 797 case and 1,208 control subjects) |
Chinese
(N = 273 case and 826 control subjects) |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. of SNPs** | OR* (95% CI) | P value | I2, % | No. of SNPs** | OR* (95% CI) | P value | I2, % | No. of SNPs** | OR* (95% CI) | P value | I2, % | |
| HDL |
60 |
0.94 (0.79–1.14) |
0.543 |
0.0 |
60 |
1.02 (0.76–1.35) |
0.917 |
12.8 |
28 |
1.16 (0.51–2.63) |
0.728 |
0.0 |
| LDL |
30 |
0.95 (0.75–1.20) |
0.651 |
0.0 |
30 |
0.87 (0.60–1.28) |
0.487 |
0.0 |
10 |
1.44 (0.31–6.70) |
0.641 |
0.0 |
| Triglycerides |
28 |
1.08 (0.96–1.22) |
0.227 |
0.0 |
28 |
1.11 (0.85–1.44) |
0.453 |
0.0 |
13 |
1.55 (0.70–3.41) |
0.280 |
0.0 |
| Total cholesterol | 39 | 0.92 (0.74–1.14) | 0.438 | 0.0 | 39 | 0.98 (0.70–1.37) | 0.889 | 5.2 | – | – | – | – |
β(SNP-lipid) estimates taken from the GLGC for Caucasians and the AGEN Consortium for Chinese differed. Therefore, we performed analyses in these two populations separately.
*ORs are for a SD of genetically induced increases in plasma lipid profiles.
**Number of SNPs included in meta-analysis.