Table 5.
MR estimate of the association between lipids and severe DR using SNPs unique to each lipid fraction and independent of glycemic traits# (primary analysis)
| All ethnicities
(N = 1,277 case and 3,980 control subjects) |
Caucasian
(N = 187 case and 435 control subjects) |
Chinese
(N = 524 case and 1,296 control subjects) |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. of SNPs* | OR† (95% CI) | P value | I2, % | No. of SNPs* | OR† (95% CI) | P value | I2, % | No. of SNPs* | OR† (95% CI) | P value | I2, % | |
| HDL |
44 |
0.98 (0.74–1.31) |
0.909 |
0.0 |
44 |
1.71 (0.59–5.02) |
0.325 |
0.0 |
21 |
1.06 (0.33–3.42) |
0.925 |
0.0 |
| LDL |
9 |
0.95 (0.39–2.36) |
0.917 |
0.0 |
9 |
0.85 (0.28–2.60) |
0.782 |
0.0 |
3 |
1.42 (0.03–62.62) |
0.855 |
0.0 |
| Triglycerides |
15 |
0.84 (0.33–2.12) |
0.712 |
0.0 |
15 |
0.61 (0.06–6.36) |
0.678 |
11.6 |
4 |
0.66 (0.05–8.85) |
0.754 |
0.0 |
| Total cholesterol | 18 | 0.68 (0.25–1.87) | 0.454 | 0.0 | 18 | 0.53 (0.06–4.79) | 0.568 | 0.0 | – | – | – | – |
β(SNP-lipid) estimates taken from the GLGC for Caucasians and the AGEN Consortium for Chinese differed. Therefore, we performed analyses in these two populations separately.
*Number of SNPs included in meta-analysis.
†ORs are for a SD of genetically induced increases in plasma lipid profiles.
#Two SNPs that showed genome-wide significant association with glycemic traits were also excluded: rs9686661and rs12328675.