Table 6.
MR estimate of the association between lipids and severe DR for all SNPs (secondary analysis)
| All ethnicities
(N = 1,277 case and 3,980 control subjects) |
Caucasian
(N = 187 case and 435 control subjects) |
Chinese
(N = 524 case and 1,296 control subjects) |
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No. of SNPs** | OR* (95% CI) | P value | I2, % | No. of SNPs** | OR* (95% CI) | P value | I2, % | No. of SNPs** | OR* (95% CI) | P value | I2, % | |
| HDL |
60 |
1.02 (0.81–1.29) |
0.861 |
0.3 |
60 |
1.49 (0.77–2.87) |
0.235 |
0.0 |
28 |
1.00 (0.54–1.85) |
0.991 |
0.0 |
| LDL |
30 |
0.94 (0.80–1.10) |
0.440 |
0.0 |
30 |
0.93 (0.73–1.18) |
0.538 |
0.0 |
10 |
0.62 (0.21–1.89) |
0.401 |
0.0 |
| Triglycerides |
28 |
1.37 (0.99–1.88) |
0.056 |
0.0 |
28 |
1.27 (0.58–2.79) |
0.552 |
21.9 |
13 |
0.90 (0.48–1.67) |
0.730 |
0.0 |
| Triglycerides† |
12 |
1.42 (1.01–2.00) |
0.044 |
2.5 |
12 |
1.43 (0.62–3.31) |
0.403 |
38.0 |
9 |
0.91 (0.48–1.73) |
0.780 |
0.0 |
| Total cholesterol | 39 | 0.69 (0.41–1.16) | 0.159 | 0.0 | 39 | 1.18 (0.36–3.90) | 0.788 | 0.0 | – | – | – | – |
β(SNP-lipid) estimates taken from the GLGC for Caucasians and the AGEN Consortium for Chinese differed. Therefore, we performed analyses in these two populations separately.
*ORs are for a SD of genetically induced increases in plasma lipid profiles.
**Number of SNPs included in meta-analysis.
†The SNPs are rs6831256 (pleiotropic with total cholesterol, LDL), rs998584 (HDL), rs731839 (HDL), rs2131925 (LDL, total cholesterol), rs1260326 (total cholesterol), rs17145738 (HDL), rs1495741 (total cholesterol), rs12678919 (HDL), rs2954029 (total cholesterol, LDL, HDL), rs174546 (LDL, total cholesterol, HDL), rs964184 (total cholesterol, HDL, LDL), and rs11613352 (HDL).