Scheme 3.
Diversifiable synthesis: a) NaH, tBu-acrylate, DMF, 80 °C, 95%, b) octanal, l-proline, NaBH3CN, EtOH, quant; c) SO4Me2, NaH, THF, 95%; d) LDA, methyl formate, THF, −78 °C, 64%; e) DDQ, CH2Cl2, 84%.
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