Table 3.
Alkylation of phenols.
| # | R1 | R5 | TAO inhibition (pIC50)a | T.b.b. Growth inhibition (pIC50)b | HepG2 Cytotox (pCC50)c |
|---|---|---|---|---|---|
| 34 | O-Geranyl | OH | 6.0 ± 0.1 | 5.5 ± 0.1 | 4.7 ± 0.1 |
| 35 | OH | O-Geranyl | 6.6 ± 0.2 | 4.9 ± 0.1 | 5.0 ± 0.1 |
a
Negative log concentration and standard deviation of compounds required for 50% inhibition of trypanosome alternative oxidase.
b
Negative log concentration and standard deviation of compounds required for 50% growth inhibition of T. b. brucei Lister427.
c
Negative log concentration and standard deviation of compounds required for 50% growth inhibition of HepG2 cell line.