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. Author manuscript; available in PMC: 2017 Nov 21.
Published in final edited form as: Acc Chem Res. 2017 Mar 21;50(3):549–555. doi: 10.1021/acs.accounts.6b00546

Figure 3.

Figure 3

Several approaches to install functionality at specific C–H bonds. (A) General scheme for the combination of borylation of an aryl C–H bond and functionalization of the intermediate arylboronate. (B) Generic scheme for palladium-catalyzed directed functionalization of aryl C–H bonds under oxidative conditions. (C) Chemoenzymatic methods for fluorination of specific C–H bonds and different positions controlled by the site-selectivity of mutant P450 enzymes.