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. Author manuscript; available in PMC: 2017 Nov 21.
Published in final edited form as: Acc Chem Res. 2017 Mar 21;50(3):549–555. doi: 10.1021/acs.accounts.6b00546

Figure 6.

Figure 6

(A) Directed evolution of P450 enzymes leading to non-native site selectivity for hydroxylation of steroids. (B) Directed evolution of P450 analogs containing iridium in the porphyrin of the active site catalyze enantioselectively.