Table 2.
Gene Set Enrichment Analysis results for miR-6510-3p and miR-4652-3p validated targets, using the SetRank package.
| A. miR-6510-3p (downregulated in HNSCC) |
Gene membership |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| Name | Description | Database | Size | SetRank score | P value | Adjusted P value | ADH5 | AKR7A2 | ABCF3 |
| GO:0006081 | Cellular aldehyde metabolic process | GOBP | 85 | 0.48 | 0.0178 | 0.0357 | X | X | . |
| hsa00980 | Metabolism of xenobiotics by cytochrome P450 | KEGG | 74 | 0.26 | 0.0178 | 0.0357 | X | X | . |
| GO:0009158 | Ribonucleoside monophosphate catabolic process | GOBP | 388 | 0.26 | 0.0294 | 0.0357 | . | . | X |
| B. miR-4652-3p (upregulated in HNSCC) | |||||||
|---|---|---|---|---|---|---|---|
| Name | Description | Database | Size | SetRank score | P value | Adjusted P value | Gene membership |
| GO:0070898 | RNA polymerase III transcriptional preinitiation complex assembly | GOBP | 2 | 0.13 | 0.0225 | 0.1798 | Supplementary Table ST3 |
| WP2446 | Retinoblastoma (RB) in Cancer | WikiPathways | 88 | 0.10 | 0.0112 | 0.1236 | Supplementary Table ST3 |
| hsa05216 | Thyroid cancer | KEGG | 29 | 0.07 | 0.0112 | 0.1236 | Supplementary Table ST3 |
| GO:0000398 | mRNA splicing, via spliceosome | GOBP | 288 | 0.07 | 0.0268 | 0.1803 | Supplementary Table ST3 |
| GO:0016579 | Protein deubiquitination | GOBP | 290 | 0.07 | 0.0306 | 0.1803 | Supplementary Table ST3 |
| GO:0000126 | Transcription factor TFIIIB complex | GOCC | 2 | 0.07 | 0.0225 | 0.1798 | Supplementary Table ST3 |
| GO:0001156 | TFIIIC-class transcription factor binding | GOMF | 3 | 0.05 | 0.0225 | 0.1798 | Supplementary Table ST3 |
| WP2377 | Integrated Pancreatic Cancer Pathway | WikiPathways | 197 | 0.04 | 0.0084 | 0.1006 | Supplementary Table ST3 |
| GO:0005200 | Structural constituent of cytoskeleton | GOMF | 110 | 0.04 | 0.0112 | 0.1236 | Supplementary Table ST3 |
| WP2857 | Mesodermal Commitment Pathway | WikiPathways | 157 | 0.04 | 0.0112 | 0.1236 | Supplementary Table ST3 |
| GO:0002072 | Optic cup morphogenesis involved in camera-type eye development | GOBP | 8 | 0.04 | 0.0199 | 0.1793 | Supplementary Table ST3 |
| R-HSA-76071 | RNA Polymerase III Transcription Initiation From Type 3 Promoter | REACTOME | 29 | 0.04 | 0.0225 | 0.1798 | Supplementary Table ST3 |
| GO:0017124 | SH3 domain binding | GOMF | 124 | 0.04 | 0.0258 | 0.1803 | Supplementary Table ST3 |
| GO:0071013 | Catalytic step 2 spliceosome | GOCC | 100 | 0.04 | 0.0268 | 0.1803 | Supplementary Table ST3 |
| R-HSA-5688426 | Deubiquitination | REACTOME | 301 | 0.04 | 0.0306 | 0.1803 | Supplementary Table ST3 |
| WP3624 | Lung fibrosis | WikiPathways | 63 | 0.04 | 0.0337 | 0.1803 | Supplementary Table ST3 |
| GO:0006412 | Translation | GOBP | 433 | 0.04 | 0.0358 | 0.1803 | Supplementary Table ST3 |
| GO:0042472 | Inner ear morphogenesis | GOBP | 100 | 0.04 | 0.0392 | 0.1803 | Supplementary Table ST3 |
| GO:0005216 | Ion channel activity | GOMF | 432 | 0.04 | 0.0444 | 0.1803 | Supplementary Table ST3 |
Rows sorted by SetRank Score (all P value < 0.05, Adj. P value < 0.2).