Table 1.

Resting Hemodynamics and Characteristics

	Baseline	3 mo	6 mo	9 mo	12 mo	P Value*
Body weight, kg	70±10	70±10	69±9	69±10	70±10	0.35
Lean body mass, kg	55.9±9.6	57.0±10.3	57.9±9.2†	57.7±9.4†	58.7±9.0†	0.002
Plasma volume, L	2.87±0.40	2.97±0.57	3.01±0.47	3.08±0.49	3.10±0.61†	0.003
Heart rate, bpm	67±6	66±6	68±8	66±9	60±5†	0.004
SBP, mm Hg	113±6	113±8	107±4†	109±8	116±7†	0.001
DBP, mm Hg	67±6	63±7	61±3†	66±9†	68±6	0.0002
Cardiac output, L/min	6.5±1.1	7.1±1.1†	7.6±1.2†	7.5±1.5†	6.7±1.1	0.0001
TPR, dyne·s·cm5	1033±180	917±167†	820±146†	838±173†	1026±168	<0.0001

Results are presented as mean±SD. DBP indicates diastolic blood pressure; SBP, systolic blood pressure; and TPR, total peripheral resistance.

^*P value from repeated measures analysis time effect from baseline to 12 months.

^†Statistically significant difference compared with baseline from mixed model repeated measures analysis.