Table 1.
Resting Hemodynamics and Characteristics
Baseline | 3 mo | 6 mo | 9 mo | 12 mo | P Value* | |
---|---|---|---|---|---|---|
Body weight, kg | 70±10 | 70±10 | 69±9 | 69±10 | 70±10 | 0.35 |
Lean body mass, kg | 55.9±9.6 | 57.0±10.3 | 57.9±9.2† | 57.7±9.4† | 58.7±9.0† | 0.002 |
Plasma volume, L | 2.87±0.40 | 2.97±0.57 | 3.01±0.47 | 3.08±0.49 | 3.10±0.61† | 0.003 |
Heart rate, bpm | 67±6 | 66±6 | 68±8 | 66±9 | 60±5† | 0.004 |
SBP, mm Hg | 113±6 | 113±8 | 107±4† | 109±8 | 116±7† | 0.001 |
DBP, mm Hg | 67±6 | 63±7 | 61±3† | 66±9† | 68±6 | 0.0002 |
Cardiac output, L/min | 6.5±1.1 | 7.1±1.1† | 7.6±1.2† | 7.5±1.5† | 6.7±1.1 | 0.0001 |
TPR, dyne·s·cm5 | 1033±180 | 917±167† | 820±146† | 838±173† | 1026±168 | <0.0001 |
Results are presented as mean±SD. DBP indicates diastolic blood pressure; SBP, systolic blood pressure; and TPR, total peripheral resistance.
P value from repeated measures analysis time effect from baseline to 12 months.
Statistically significant difference compared with baseline from mixed model repeated measures analysis.