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. Author manuscript; available in PMC: 2018 Dec 1.
Published in final edited form as: J Immunol. 2017 Oct 30;199(11):3828–3839. doi: 10.4049/jimmunol.1700426

Figure 4. PMNs show increased uptake of bacteria in the presence of FH6-7/hFc.

Figure 4

Non-opsonized S. pyogenes AP1 was incubated in human blood in the presence and absence of FH6-7/hFc. Leukocytes were stained and analyzed using Amnis flowsight technology. PMNs with ingested bacteria were discriminated from extracellular bacteria (A). FH6-7/hFc significantly increased phagocytosis rate of bacteria (B). PMNs treated with cytochalasin D served as a negative control. Mean from 5 individual donors (indicated by color) are shown. Statistical significance of differences was calculated using a matched 1-way ANOVA with Tukey’s post-test (overall p value in B p<0.0063); **, p<0.01.