Table 2.

Summary of comparisons between MEKARP and CSC

MEK inhibitor associated retinopathy/pigment epitheliopathy (MEKARP)	Central Serous Chorioretinopathy (CSC)
Bilateral in 92%	Up to 40% bilateral
Multifocal fluid foci (mean 6 foci per eye)	Unifocal or multifocal foci
84% eyes with subfoveal focus, other foci conglomerate around the arcades	Foci in macula
Fluid foci have four configurations: dome, caterpillar, wavy or splitting	Fluid focus usually dome configuration
Fluid foci without gravitational dependency: shape of mercury globules	Fluid foci with gravitational dependency and inferior tracking of fluid
Fluid located in sub-interdigitation zone (IZ): between retinal pigment epithelium (RPE) and IZ
No RPE detachments or intraretinal/choroidal hyperreflectile dots	Majority have RPE detachments or intraretinal/choroidal hyperreflectile dots
Elongation of IZ during fluid accumulation (38%)
During fluid accumulation, IZ distinguishable from ellipzoid zone (EZ) and RPE
Fluid accumulation makes IZ visible in eyes with indistinguishable IZ at baseline
RPE, IZ and ellipsoid zone layers remain hyperreflectile and clearly distinguishable, both at the time of fluid accumulation and its resolution	IZ and EZ can become disturbed and may not reconstitute
Choroidal thickness normal and remains unchanged during fluid accumulation and resolution	Abnormally increased choroidal thickness in diseased and fellow eye
Symptoms include: blurry vision, metamorphopsia, dyschromatopsia	Symptoms include: blurry vision, metamorphopsia, dyschromatopsia
Majority of patients in this series are female (perhaps reflective of primary cancer diagnosis)	More common in male patients