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. Author manuscript; available in PMC: 2018 Nov 15.
Published in final edited form as: Arch Biochem Biophys. 2017 Sep 27;634:38–46. doi: 10.1016/j.abb.2017.09.017

Figure 2.

Figure 2

cTnI-MD truncations affected the tension-pCa relationship differently at long vs. short SL. Developed tension-pCa relationships for A) cTnI(WT) (●) and (○) at 2.2 and 1.9µm SLs, respectively; B) cTnI(1–167) (▼) and (▽) at 2.2 and 1.9µm SLs, respectively; and C) cTnI(1–193) (▲) and (∆) at 2.2 and 1.9µm SLs, respectively. Lines represent 3-parameter Hill fits to the tension-pCa data, with the fine dashed line representing cTnI(WT) fit at 1.9µm SL, and bold dashed line for cTnI(WT) fit at 2.2µm SL replotted in panel B and C.

*: SL effect for cTnI(WT); P < 0.05

†: Truncation effect compared to cTnI(WT) at same SL; P < 0.05