Table 2.

Biochemical liver function parameters and Ishak scores

	Sham-operated rats	Mildly cholestatic rats	Severely cholestatic rats
Albumin (g/L)	36.1 ± 3.3	35.8 ± 3.8	31.2 ± 3.7ad
ALT (U/L)	43.7 ± 8.1	44.2 ± 8.8	115.3 ± 32.4cf
AST (U/L)	92.2 ± 41.6	103.5 ± 33.0	402.7 ± 136.6cf
γGT (U/L)	0.1 ± 0.6	0.5 ± 0.5	52.4 ± 34.8be
ALKP (U/L)	133.9 ± 47.1	150.8 ± 38.0	320.1 ± 107.2cf
Conjugated bilirubin (mmol/L)	0.8 ± 0.3	0.7 ± 0.3	133.1 ± 56.9cf
Total bilirubin (mmol/L)	1.1 ± 0.6	1.0 ± 0.3	151.2 ± 64.1cf
Ishak score	0	1-3 (1)	4-6 (5)

The results are given as mean ± SD obtained from 8 rats of each group. Ishak scores are given as range (median).

^aP < 0.05;

^bP < 0.01;

^cP < 0.001 vs sham-operated rats;

^dP < 0.05;

^eP < 0.01;

^fP < 0.001 vs mildly cholestatic rats.