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. 2017 Jul;108:500–516. doi: 10.1016/j.freeradbiomed.2017.04.025

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Crown Copyright © 2017 Published by Elsevier Inc. All rights reserved.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig. 7. — Redox-dependent mechanisms regulating H₂S production by CSE. A) H₂O₂ (generated from an unknown source) can enhance CSE activity. B) Nox4 represents a potential source of H₂O₂ that can upregulate the transcriptional expression of CSE through an ATF4-dependent mechanism. C) NADPH-derived O₂^-/H₂O₂ can activate Nrf2 leading to increased CSE transcription. These redox-dependent transcriptional and post-translational changes in CSE expression may lead to altered H₂S production. CSE: Cystathionine-γ-lyase.