Table 3.
Odds ratios (ORs) and 95% confidence intervals (CIs) of the clinical status and FSCN1 rs3801004 and rs2966447 genotypic frequencies in patients with breast cancer.
| Gene Genotypes | Patients N = 316 (%) | OR (95% CI) | AOR (95% CI) | |
|---|---|---|---|---|
| Clinical Stage | ||||
| Stage I/II | Stage III/IV | |||
| rs3801004 | ||||
| CC | 231 (78.3) | 64 (21.7) | 1.00 (reference) | 1.00 (reference) |
| CG + GG | 12 (57.1) | 9 (42.9) | 2.707 (1.092–6.709)* | 2.540 (1.011–6.379)* |
| rs2966447 | ||||
| AA | 183 (77.9) | 52 (22.1) | 1.00 (reference) | 1.00 (reference) |
| AT + TT | 60 (74.1) | 21 (25.9) | 1.232 (0.686–2.210) | 1.275 (0.707–2.300) |
| Tumor size | ||||
| ≦T2 | >T2 | |||
| rs3801004 | ||||
| CC | 281 (95.3) | 14 (4.7) | 1.00 (reference) | 1.00 (reference) |
| CG + GG | 19 (90.5) | 2 (9.5) | 2.113 (0.447–9.982) | 1.958 (0.402–9.531) |
| rs2966447 | ||||
| AA | 222 (94.5) | 13 (5.5) | 1.00 (reference) | 1.00 (reference) |
| AT + TT | 78 (96.3) | 3 (3.7) | 0.657 (0.182–2.366) | 0.693 (0.191–2.507) |
| Lymph node metastasis | ||||
| N0 + N1 | N2 + N3 | |||
| rs3801004 | ||||
| CC | 236 (80.0) | 59 (20.0) | 1.00 (reference) | 1.00 (reference) |
| CG + GG | 12 (57.1) | 9 (42.9) | 3.000 (1.207–7.454)* | 2.804 (1.112–7.070)* |
| rs2966447 | ||||
| AA | 187 (79.6) | 48 (20.4) | 1.00 (reference) | 1.00 (reference) |
| AT + TT | 61 (75.3) | 21 (24.7) | 1.277 (0.704–2.319) | 1.324 (0.725–2.419) |
| Distant metastasis | ||||
| M0 | M1 | |||
| rs3801004 | ||||
| CC | 286 (93.5) | 9 (3.1) | 1.00 (reference) | 1.00 (reference) |
| CG + GG | 20 (95.2) | 1 (4.8) | 1.589 (0.192–13.173) | 2.395 (0.275–20.879) |
| rs2966447 | ||||
| AA | 226 (96.2) | 9 (3.8) | 1.00 (reference) | 1.00 (reference) |
| AT + TT | 80 (98.8) | 1 (1.2) | 0.314 (0.039–2.517) | 0.295 (0.037–2.379) |
| Pathologic grade | ||||
| G1 + G2 | G3 | |||
| rs3801004 | ||||
| CC | 203 (68.8) | 92 (31.2) | 1.00 (reference) | 1.00 (reference) |
| CG + GG | 16 (76.2) | 5 (23.8) | 0.690 (0.245–1.939) | 0.794 (0.278–2.268) |
| rs2966447 | ||||
| AA | 171 (72.8) | 64 (27.2) | 1.00 (reference) | 1.00 (reference) |
| AT + TT | 48 (59.3) | 33 (40.7) | 1.837 (1.083–3.115)* | 1.734 (1.016–2.962)* |
The ORs with their 95% CIs were estimated by logistic regression analysis. The adjusted odds ratios (AORs) with their 95% confidence intervals (CIs) were estimated by multiple logistic regression analysis that controlled for smoking, alcohol consumption, and age. *p < 0.05 was statistically significant.