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. 2017 Nov 21;7:15928. doi: 10.1038/s41598-017-15918-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Transgenic expression of BCL2 rescues the generation of NCOR1 cKO^Cd4 SP thymocytes. (a) Flow cytometry analysis of CD4 and CD8 expression on thymocytes isolated from WT and NCOR1 cKO^Cd4 mice that are non-transgenic (left panel) or transgenic for Vav-BCL2 (right panel). (b) Percentages (upper panel) and cell numbers (lower panel) of DN, DP, CD4SP and TCRβ^hi CD8SP thymocytes in WT and NCOR1 cKO^Cd4 mice that are non-transgenic or transgenic for Vav-BCL2 are shown. (c) Flow cytometry analysis of CD69 and TCRβ expression on thymocytes isolated from WT and NCOR1 cKO^Cd4 mice that are non-transgenic (left panel) or transgenic for Vav-BCL2 (right panel). (d) Percentages (upper panel) and cell numbers (lower panel) of TCRβ^−/loCD69⁻, TCRβ^loCD69⁺, TCRβ^hiCD69⁺ and TCRβ^hiCD69⁻ thymocytes in WT and NCOR1 cKO^Cd4 mice that are non-transgenic and transgenic for Vav-BCL2 are indicated. (a,c) Numbers indicate the percentage of cells in the respective quadrants or regions. (b,d) Thick horizontal bars indicate the mean; *P < 0.05, **P < 0.01 and ***P < 0.001, n.s., not significant; unpaired two-tailed Student’s t-test. Data are representative (a,c) or show the summary (b,d) of 9–15 (for non transgenic mice; non-tg) and 5–9 (for tgVav-BCL2 mice) mice that were analyzed in 4–7 independent experiments. (b,d) The data for WT and NCOR1 cKO^Cd4 mice in (b; except DN subsets) and (d) were already shown in Figures 2b and 4e, respectively.