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(A) Pressure–dimension loops before (Left) and after (Right) infusion of DEA/NO, a NO donor. Unlike AS, the NO donor did not significantly alter contractility. However, there was a decline in systemic resistance reflected by widening of the loop with less preload change. (B) Summary results (n = 3) show the lack of contractile increase (Ees or DEDV) with DEA/NO, but arterial resistance (SVR) decreased by 25% .
