Table 1.

Inclusion and exclusion criteria

Inclusion criteria

Age between 16 and 75 years

UP ≧3.5 g/day and serum albumin level ≦3.0 g/dL

PSL treatment alone for >4 weeks did not decrease UP to <1 g/day

Membranous nephropathy was diagnosed by renal biopsy

No history of treatment with MZR before registration

Informed consent form signed voluntarily by the participant

Exclusion criteria

Patients with creatinine clearance <50 mL/min or serum creatinine >2 mg/dL

Patients with a history of severe hypersensitive reaction to MZR

Patients previously treated with MZR

Patients with a white blood cell count of <3000/mm3 in peripheral blood

Patients currently pregnant, suspected to be pregnant, or nursing

Patients with any severe complication

Patients with any severe bacterial, fungal, or viral infection

Patients determined to be inappropriate for participation in the study by an investigator

UP urine protein, PSL prednisolone, MZR mizoribine