Fig. 3.

Screen for modulators of BDNF-induced Arc expression and histone acetylation. a Screen setup and technical details. b Waterfall plot of 293 screen compounds for which reliable data was collected at the tested concentration. Highlighted as red dots are KDAC inhibitor compounds that increased abundance of nuclear Arc. Data are presented as fold-change normalized to DMSO control plus BDNF (±1-fold-change, dashed line). c Joint representation as a Z-score of the acetyl-H3K9 and Arc immunofluorescence signals measured in neuronal nuclei for the top 100 potentiators of BDNF-induced Arc expression