Table 7.
Multivariate Cox proportional hazards analyses for 28-day all-cause mortality per increase of chloride concentration for 24, 48 & 72 hours in normochloremic group.
| Variables (n = 297) | Multivariate | |||||
|---|---|---|---|---|---|---|
| 24 hours | 48 hours | 72 hours | ||||
| HR (95% CI) | Variables (n = 297) | HR (95% CI) | Variables (n = 297) | HR (95% CI) | Variables (n = 297) | |
| Delta chloride (per 1 mEq/L increase of chloride level) | 0.930 (0.853–1.014) | 0.098 | 0.986 (0.907–1.072) | 0.747 | 0.975 (0.896–1.062) | 0.562 |
| Age (per 1year increase) | 1.008 (0.979–1.037) | 0.604 | 1.009 (0.977–1.042) | 0.576 | 1.004 (0.972–1.038) | 0.792 |
| Male (vs. Female) | 1.372 (0.711–2.648) | 0.345 | 1.485 (0.704–3.133) | 0.300 | 1.848 (0.827–4.127) | 0.134 |
| SOFA score (per 1unit increase) | 1.117 (1.000–1.248) | 0.050 | 1.134 (1.005–1.279) | 0.042 | 1.124 (0.992–1.274) | 0.066 |
| BUN (per 1 mg/dL increase) | 1.013 (1.003–1.023) | 0.008 | 1.013 (1.001–1.024) | 0.028 | 1.014 (1.002–1.026) | 0.027 |
| Albumin (per 1 g/dL increase) | 0.527 (0.328–0.845) | 0.008 | 0.334 (0.201–0.556) | <0.001 | 0.339 (0.200–0.573) | <0.001 |
| Total CO2 (per 1mEq/L increase) | 0.996 (0.918–1.080) | 0.915 | 1.024 (0.933–1.123) | 0.620 | 1.027 (0.934–1.130) | 0.579 |
Abbreviations; HR, hazard ratio; CI, confidence interval; SOFA, sequential organ failure assessment; BUN, blood urea nitrogen.