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. 2017 Nov 21;7:15888. doi: 10.1038/s41598-017-15752-4

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) P-values of SNP association between RSV patients and controls in different control groups and in the merged control group “ALL” (IBS + CEU + GBR + TSI). (B) P-values of gene burden association test between RSV patients and controls in different control groups and in the merged control group “ALL” considering all variants in genes. (C) P-values of gene burden association test between RSV patients and controls in different control groups and in the merged control group “ALL” considering only rare variants in genes. The vertical grey shadow in the figures indicates the threshold for the adjusted Bonferroni P-value according to the number of independent tests considering CEU, GBR, TSI, and ALL as additional control groups of the best SNPs (n = 12) and gene candidates (one gene when collapsing common variants and four genes when collapsing rare variants). The red vertical line indicates the genome Bonferroni threshold considering genes and all the common SNPs that are shared between cohorts.