Table 4.
Association test of SNPs collapsed by genes and using average CADD per gene as a covariant for the association test.
| Gene | Chr. | n° SNP | P-valueIBS | P-valueCEU | P-valueGBR | P-valueTSI | P-valueALL | P-valueEC |
|---|---|---|---|---|---|---|---|---|
| CDC27 | 17 | 6 | 4.97 × 10−07 | 4.20 × 10−06 | 5.29 × 10−09 | 1.92 × 10−08 | 1.01 × 10−10 | 4.3 × 10−11 |
| OR8U1/ OR8U8 | 3 | 9 | 7.60 × 10−10 | 1.22 × 10−08 | 8.10 × 10−07 | 2.14 × 10−08 | 1.69 × 10−14 | — |
| TAS2R19 | 4 | 6 | 2.30 × 10−07 | 2.25 × 10−09 | 7.41 × 10−08 | 3.30 × 10−07 | 9.21 × 10−15 | — |
| MUC6 | 3 | 18 | 3.00 × 10−07 | 3.10 × 10−09 | 5.85 × 10−11 | 3.46 × 10−06 | 3.12 × 10−11 | 7.84 × 10−02 |
| LPA | 19 | 12 | 1.34 × 10−05 | 3.96 × 10−05 | 1.44 × 10−03 | 1.07 × 10−04 | 1.07 × 10−06 | 1.07 × 10−03 |
CDC27 appeared as statistically significant when analyzing common variants (MAF ≥ 0.05), while the other genes appeared as statically significant when analyzing rare variants (MAF < 0.05). The genes showing the lowest P-value against the IBS control group were further tested using CEU, GRB, and TSI as control groups and merging the three sample sets into a single one (“ALL” = IBS + CEU + GBR + TSI); a hyphen in column “P-valueEC” indicates that there is not enough genetic information available in the Spanish control groups.