Figure 2.

Percent Repolarization. Different pharmacologic interventions targeting specific ion channels led to changes in APD morphology. (a) Box-and-whisker (B&W) plots of % ∆APD80 from baseline to isoprenaline indicate that APD did not alter among different % repolarization. (b) I_Ks blockade with JNJ-303 linearly increased % ∆APD80 as % repolarization increased, indicating that I_Ks was more prominent at the latter phases of AP. (c) I_Kr block with E-4031 increased % ∆APD80 as % repolarization was increased, peaking at approximately 80–85% to indicate that I_Kr contributes the most at 80–85% repolarization.