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. 2017 Nov 21;7:15966. doi: 10.1038/s41598-017-16226-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Role of miR-500a-5p in the response to oxidative stress. (a) MCF-7 and T47D cells were exposed to increasing concentrations of H₂O₂ within their respective sublethal range. RNA extracted under these conditions was reverse-transcribed and tested for expression of miR-500a-5p guide strand (upper panels), and miR-500a-3p passenger strand (bottom panels). (b) Two selected targets of miR-500a-5p (i.e. TXNRD1 and NFEL2L) were studied under the same experimental conditions. (*) indicates P value < 0.05.