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Extreme COOH-terminal domain is sufficient to coordinate basolateral membrane localization. Reconstructed z-plane confocal images of MDCK cells stably transfected with two different CD4Kir 2.3 chimeras. One contains residues 413–445; the other is truncated after residue 431, removing the sorting signal defined above. The final 32 aa are sufficient for basolateral membrane expression. As defined above, the final 14 aa are necessary to direct basolateral membrane targeting.
