Table 2.
Pharmacokinetic parameters for GSK2793660 following single and repeat doses
| Treatment | Cmax (ng ml–1)a | AUC(0–24) (ng h ml–1)a | tmax (h)b | t1/2 (h)a |
|---|---|---|---|---|
| GSK2793660, 0.5 mg | 1.04 (46.3) | 0.326 (72.4) | 0.5 (0.25–0.50) | ND[Link] |
| GSK2793660, 2 mg | 9.61 (31.1) | 8.460 (36.8) | 0.5 (0.25–1.00) | 0.636 (14.0) |
| GSK2793660, 6 mg | 24.53 (54.1) | 47.967 (45.0) | 1.0 (0.50–3.00) | 1.415 (40.5) |
| GSK2793660, 12 mg | 50.69 (41.5) | 95.853 (47.9) | 0.85 (0.50–3.00) | 1.732 (30.1) |
| GSK2793660, 20 mg | 126.36 (49.5) | 255.883 (28.3) | 0.75 (0.5–1.5) | 1.631 (11.2) |
| GSK2793660 12 mg x 21 days | Day 1 (fasted) | |||
| 49.00 (61.8) | 86.977 (41.9) | 0.75 (0.50–1.50) | 1.384 (24.9) | |
| Day 2 (fed) | ||||
| 51.86 (42.4) | 139.399 (27.1) | 1.000 (1.00–3.00) | 1.444 (20.9) | |
| Day 21 (fasted) | ||||
| 72.56 (39.6) | 127.591 (22.1) | 1.00 (0.50–2.00) | 1.566 (18.2) | |
a
Geometric mean (CV%);
b
Median (range);
ND: not determined