Figure 6.

Top Left. Fused sagittal slice of baseline ¹⁸F-NaF-PET/CT and high radionuclide uptake in multiple vertebral bodies. Top middle. Fused sagittal slice ¹⁸F-NaF-PET/CT after 3 cycles of ²²³Ra. Top Right. Fused sagittal slice ¹⁸F-NaF-PET/CT after 6 cycles of ²²³Ra plus ADT, note the important osteoblastic activity. Middle. Sagittal slices corresponding only a CT baseline, CT after 3 cycles of ²²³Ra and CT after 6 cycles of ²²³Ra plus ADT, note the increased sclerotic changes. Lower Left. multiple sites of focal high radionuclide uptake that result in metastatic bone disease predominantly blastic type axial skeleton in the MIP ¹⁸F-NaF-PET. Lower middle. MIP ¹⁸F-NaF PET after 3 cycles of ²²³Ra. Lower Right. MIP ¹⁸F-NaF-PET after 6 cycles of ²²³Ra plus ADT, note the important decreased of osteoblastic activity (patient 4).