Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Sep 25;58(9):632–643. doi: 10.1002/em.22137

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2017 Her Majesty the Queen in Right of Canada 2017. Reproduced with permission of the Minister of Health, Canada. Environmental and Molecular Mutagenesis.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Genotoxic potency analysis of dimethylnitrosamine (DMN) determined using the Muta™Mouse (blue) or BigBlue^® Mouse (orange) transgenic rodent assays. BMD analysis, with endpoint‐specific BMR values, was conducted to compare BMDs determined using two TGR assay variants. Two‐sided 90% confidence intervals of the BMD, based on BMRs indicated beneath each tissue, were calculated from mutant frequency (MF) dose‐response data (i.e., lacZ or lacI transgene) in liver tissue using two different BMD models: the exponential (upper interval per pair) or the Hill (lower interval per pair). Datasets were analyzed individually. The underlying dose‐response data and fitted BMD models are presented in Supporting Information Figure S4.