Table 5.
Uni‐ and multivariate Cox‐proportional hazards regression analysis to explore factors associated with infections during thiopurine treatment
| Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|
| Hazard ratio (95% CIs) | P‐value | Hazard ratio (95% CIs) | P‐value | |
| Sex, male | 0.67 (0.40‐1.15) | .15 | ||
| Age, per 10‐year | 1.84 (1.06‐3.21) | .03 | 2.07 (1.18‐3.63) | .01 |
| Active smoker | 1.58 (0.90‐2.76) | .11 | ||
| Week 0 WBC count, 109/L | 0.95 (0.88‐1.02) | .17 | ||
| Leucopenia | 1.66 (0.75‐3.65) | .21 | ||
| Concomitant use of biologics | 2.03 (1.08‐3.83) | .03 | 2.15 (1.14‐4.07) | .02 |
Infections were classified according to the Common Terminology Criteria for Adverse Events 4.0 (version 4.0). Only infections grade 2 or higher were included.
WBC, white blood cell.