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. 2017 Oct 20;56(47):14963–14967. doi: 10.1002/anie.201708847

Figure 3.

Figure 3

a) Representation of disulfide stapling of native antibody sequences using an oxetane graft. b),c) Total ion chromatogram, combined ion series and deconvoluted mass spectrum reconstructed from the ion series using the MaxEnt algorithm. b) Fab‐Her‐1 (pdb ID Fab‐Her: 1N8Z) and c) DesAb‐Aβ3‐91 (3D model of DesAb‐Aβ3‐9 generated using ABodyBuilder, see main text). d) BLI and fit curves obtained for Fab‐Her‐1, together with the derived K D constants for Fab‐Her and Fab‐Her‐1. e) CD spectra of DesAb‐Aβ3‐9 and DesAb‐Aβ3‐91.